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The medication is primarily eliminated through protein catabolism rather than traditional hepatic metabolism, meaning liver disease typically does not substantially affect elimination rates
Correlation between spermatogenesis disorders and rat testes CYP2E1 mRNA contents under experimental alcoholism or type I diabetes
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The COG4 gene is located on chromosome 16q22.1 (close to the location of the COG8 gene) and is composed of 20 exons that generate three alternatively spliced mRNAs encoding three distinct protein isoforms: isoform 1 (789 amino acids), isoform 2 (768 amino acids), and isoform 3 (647 amino acids)
